Cell Forté Serum | Human Stem Cell Skincare | Angela Caglia

Shake well. Apply a dropper of Cell Forte Serum on your fingertips, then immediately apply to cleansed, dry face and neck in the morning and evening. You may use other products afterward as part of your everyday routine. If using Elderberry Bakuchiol Serum or other exfoliant in your routine, cut back to two to three times per week.

FOR BEST RESULTS, Angela recommends applying in the morning and evening. Each bottle should last approximately 30 days with twice daily use.

BENEFITS:

*Reduces the appearance of sun damage
*Improves the appearance of fine lines and wrinkles
*Reduces the look of hyperpigmentation
*Improves the look and feel of the skin

FEATURES:

*Suitable for all skin types
*4 in 1 product
*Fragrance- and dye-free
*Cruelty-free
*Clean, allergen-free formulation
*Multi-level hydration
*Luxurious silky, highly absorbable texture
*Human MSC conditioned media is produced in a cGMP laboratory
*Small-batched produced

RESULTS from twice daily use of Cell Forte Serum, am and pm, after a 28-day perception study with 39 women aged 40-60.

91% agreed it helped reduce the look of hyperpigmentation
90% said skin looks more youthful
87% said skin increases luminosity
85% said skin elasticity improved
85% said it fades the look of fine lines and wrinkles

Scientific and Clinical Studies:

A growing body of peer-reviewed research supports the safety, stability, and efficacy of adipose-derived mesenchymal stem cell-conditioned media (ADMSC-CM) and its exosomes for improving visible signs of aging, enhancing barrier function, and enhancing overall skin quality. The studies below represent independent and industry-sponsored research; Cell Forté Serum is a cosmetic product inspired by this science, not a drug or medical treatment.

CLINICAL TRIALS ON ADMSC-CM FOR SKIN:

Kim et al., 2020 (Biomedical Dermatology)
In a 4-week randomized, double-blind, placebo-controlled clinical trial of 60 women with photoaged skin, creams containing 5% adipose-derived mesenchymal stem cell–conditioned media (ADMSC-CM) significantly improved hydration, barrier function (reduced TEWL), pigmentation, and wrinkle depth compared with placebo. The group using encapsulated ADMSC-CM achieved the most dramatic improvements, with no adverse events reported.

👉 Read study: https://biomeddermatol.biomedcentral.com/articles/10.1186/s41702-020-0056-9
Lee et al., 2021 (Journal of Cosmetic Dermatology)
In a split-face, post-laser study, patients applied a moisturizer containing ADMSC-CM + niacinamide on one side and niacinamide alone on the other. The ADMSC-CM side showed greater reductions in wrinkles, pigmentation, and redness, along with higher collagen levels and lower inflammation markers (MMP-1, MMP-2). This demonstrates that ADMSC-CM helps restore collagen and calm inflammation for faster skin recovery.

👉 Read study: https://pubmed.ncbi.nlm.nih.gov/33103316/
Ahn et al., 2023 (Annals of Dermatology)
Although conducted with umbilical-cord MSC-conditioned media, this split-face study found significantly faster barrier recovery, lower redness, and improved moisture retention on the MSC-treated side after laser-induced irritation. These results support the broader benefits of MSC-derived conditioned media for sensitive, reactive, and barrier-compromised skin.

👉 Read study: https://anndermatol.org/DOIx.php?id=10.5021/ad.21.287

SAFETY & STABILITY RESEARCH:

Maguire & Friedman, 2020 (Future Science OA)
Comprehensive safety testing of a therapeutic product combining stem cell-released molecules from adipose mesenchymal stem cells and fibroblasts. Human Repeat Insult Patch Testing demonstrated no irritation, with additional studies confirming no ocular pathology, no tumorigenicity, negative Ames mutagenicity results, no cellular toxicity, and no protein misfolding in collagen or keratin structures.

👉 Read study: https://pmc.ncbi.nlm.nih.gov/articles/PMC7421258/
Kadoya et al., 2025 (Dermatologic Surgery)
This landmark study—funded by Allergan Aesthetics and published in Dermatologic Surgery—was the first to confirm that exosomes can remain structurally stable and biologically active within a topical cosmetic formulation. Using advanced imaging and protein analysis (TEM, NTA, and ELISA), researchers verified that the exosomes retained their intact spherical shape (~150 nm) and hallmark surface proteins (CD9, CD63, CD81) after formulation. Proteomic and gene-expression analyses revealed enrichment in collagen, elastin, and wound-healing pathways.

👉 Read abstract: https://journals.lww.com/dermatologicsurgery/fulltext/2025/09001/isolation___characterization_of_stable_exosomes_in.4.aspx

MECHANISM OF ACTION: HOW STEM CELL CONDITIONED MEDIA WORKS:

Maguire, 2013 (Communicative & Integrative Biology)
Foundational research establishing that up to 80% of the therapeutic effect of adult stem cells occurs through paracrine-mediated actions—the molecules they release—rather than through direct cell differentiation. This validates the science behind using conditioned media (the beneficial molecules) rather than live stem cells themselves.

👉 Read study: https://pmc.ncbi.nlm.nih.gov/articles/PMC3925653/
Maguire & Friedman, 2015 (World Journal of Stem Cells)
Describes how stem cell released molecules (SRM) from multiple stem cell types work synergistically to support tissue maintenance and repair through multiple biological pathways, mimicking the body's natural healing processes.

👉 Read study: https://pmc.ncbi.nlm.nih.gov/articles/PMC4444614/
Maguire, 2019 (Journal of Clinical and Aesthetic Dermatology)
This review highlights the safety and efficacy advantages of adipose-derived stem cells and fibroblasts for skin applications. The secretome from these cells provides anti-inflammatory, regenerative, and tissue-remodeling benefits relevant to skin health and appearance.

👉 Read study: https://pmc.ncbi.nlm.nih.gov/articles/PMC6715117/

FOUNDATIONAL SKIN SCIENCE:
Gurtner et al., 2008 (Nature)
This landmark review established the foundational science of wound repair and regeneration, explaining how multiple biological pathways coordinate after skin injury and how certain conditions allow tissue to regenerate rather than scar—principles that inform modern approaches to skin rejuvenation.

👉 Read study: https://www.nature.com/articles/nature07039
Liu et al., 2014 (Journal of Investigative Dermatology)
Demonstrated that mesenchymal stem cells help regulate inflammatory responses through secretion of the protein TSG-6, supporting calmer, more balanced skin. This research contributes to understanding how MSC-derived molecules may benefit reactive or inflammation-prone skin.

👉 Read study: https://pubmed.ncbi.nlm.nih.gov/24714203/

Summary:

Collectively, this research demonstrates that adipose-derived stem cell-conditioned media and exosomes—when properly stabilized—can support the appearance of firmer, smoother, more hydrated, and visibly rejuvenated skin. These studies also confirm that exosomes can remain stable and functional in cosmetic formulations, supporting cellular communication, collagen production, and overall skin vitality.

Important Notice:

Cell Forté Serum is a cosmetic product formulated with Human Adipose-Derived Mesenchymal Stem Cell Conditioned Media. The studies referenced above represent published research on this ingredient category and are provided for educational purposes only. They do not constitute claims that Cell Forté Serum will produce identical results. Individual results may vary.

This product is intended for cosmetic use only. It is designed to support the appearance of healthier, more youthful-looking skin and is not intended to diagnose, treat, cure, or prevent any disease or medical condition.

This serum reduces the appearance of fine lines and wrinkles and improves the brightness and radiance of your skin within four weeks without disrupting the skin’s natural barrier. The result is younger-acting skin, significantly enhanced brightness and clarity, and smoother texture and tone.

1 fl. oz.

Human Adipose Mesenchymal Stem Cell (MSC) Conditioned Media:

Conditioned media is a powerful byproduct generated when human stem cells are cultured and nurtured in a controlled environment. During this process, stem cells release powerful growth factors, cytokines, and proteins that hold the key to skin rejuvenation.

BIOMSC™️:

Proprietary blend of our protein-rich human-derived 'conditioned media' and a combination of synthetic peptides and hydrators.

Tremella Fuciformis Sporocarp Extract:

Clinically proven to be 10x more hydrating than hyaluronic acid.

Lipid Lock Technology™️:

Proprietary bio-identical natural delivery system.

Bacillus Ferment Extract:

Probiotic maintains a healthy skin microbiome, balanced pH, and strengthens the skin barrier.

Hyaluronic Acid:

Different molecular weights for extra hydration.

FULL INGREDIENT LIST:

Water (Aqua), Propanediol, Human Adipose-Derived Stem Cell Conditioned Media, sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, sh-Polypeptide-11, Acetyl Glutamine, Alanine, Allantoin, Arginine, Bacillus Ferment, Bacillus/Folic Acid Ferment Filtrate extract, Betaine, Bisabolol, Citric Acid, Glutamic Acid, Glycerin, Glycine, Hydrolyzed Eragrostis Tef Seed Extract, Hydrolyzed Eragrostis Tef Seed Extract, Hydrolyzed Hyaluronic Acid, Lecithin, Limnanthes Alba (Meadowfoam) Seed Oil, Lysine HCl, Niacinamide, Panthenol, PCA, Proline, Pullulan, Serine, Sodium Hyaluronate, Sodium Lactate, Sodium PCA, Threonine, Tremella Fuciformis Sporocarp Extract, Xanthan Gum, Sclerotium Gum, Caprylyl Glycol, Ethylhexylglycerin, 1,2-Hexanediol, Trisodium Ethylenediamine Disuccinate, Sodium Benzoate